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Milnacipran: A serotonin and norepinephrine reuptake inhibitor for the management of fibromyalgia syndrome
Milnacipran was recently approved by FDA for the management of fibromyalgia syndrome. Clinical trials have demonstrated that this agent may be a reasonable alternative or adjunct therapy for patients with fibromyalgia syndrome who are unable to tolerate first-line tricyclic antidepressant therapy.
Clinical News
Elevated CRP alone does not justify statin treatment
C-reactive protein (CRP) does not add predictive value to traditional cardiovascular risk factors, and there does not appear to be a causal association between CRP and coronary heart disease (CHD), according to results of two studies published in the July 1, 2009, issue of the Journal of the American Medical Association.
ADHD medications may be linked to sudden unexplained death
A matched, case-control analysis demonstrated an association between the use of stimulant medications (used to treat attention-deficit/hyperactivity disorder [ADHD]) and sudden unexplained death in children and adolescents.
Trial of sunitinib plus paclitaxel for advanced breast cancer discontinued
Pfizer is discontinuing a phase 3 study of sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for the first-line treatment of patients with advanced breast cancer.

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MEDWATCH DRUG SAFETY UPDATES
Lantus (insulin glargine)
Varenicline (marketed as Chantix) and Bupropion (marketed as Zyban, Wellbutrin, and generics)
Nestle Toll House Prepackaged, Refrigerated Cookie Dough
Stamina-Rx Dietary Supplement Products
Cefepime (marketed as Maxipime) Update of Ongoing Safety Review

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